Linked Life Data

6165803

Source:http://linkedlifedata.com/resource/pubmed/id/6165803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-8-20
pubmed:abstractText
Radioimmunoassays were developed for antibodies to denaturated forms of HBsAg (reduced and alkylated in an isotonic buffer (RAHBs) or in 8 M urea-HBs) or reduced in 8M urea but not alkylated). These tests revealed that intact HBsAg and RA-HBs shared common antigenic determinants, termed Re[Imai et al, 1974]. Anti-Re is elicited in the course of immune response to intact HBsAg in humans and experimental animals. Denaturation in 8 M urea and alkylation causes the appearance of additional antigenic determinants, the specificity of which is affected by the reagent used for alkylation. Reduction in 8 M urea followed by treatment with iodoacetate reveals antigenic sites common for HBsAg and some human serum proteins. Antibodies specific for the Le Bouvier determinants of HBsAg are probably not the appropriate probe for detection of primary translational products of the hepatitis B virus genome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-6615
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Antibodies as immunological probes for studying the denaturation of HBsAg.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.