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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1981-8-27
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pubmed:abstractText |
This study investigates the endogenous kallikrein-kinin system's role as a modulator of vasopressin action in the toad urinary bladder. Kalli-krein inhibition by aprotinin, which results in decreased kinin production, significantly increased both vasopressin and 8-Br-cyclic (c) AMP-stimulated water flow. Kinin potentiation by the kininase II inhibitor captopril (SQ 14225) significantly decreased vasopressin and 8-Br-cAMP-stimulated water flow. In contrast to water flow, vasopressin-stimulated urea permeability was decreased by aprotinin and increased by captopril. We conclude that the endogenous kallikrein-kinin system represents a significant modulator of vasopressin action and it permits separate control of vasopressin-stimulated water flow and solute transport.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-13587824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-14166162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-14419754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-191908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-199620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-226713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-226714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-39188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-40606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-4114209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-4621713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-5780194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-6159795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-6773984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-6903427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165739-965714
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1792-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6165739-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:6165739-Animals,
pubmed-meshheading:6165739-Anura,
pubmed-meshheading:6165739-Aprotinin,
pubmed-meshheading:6165739-Biological Transport,
pubmed-meshheading:6165739-Captopril,
pubmed-meshheading:6165739-Cell Membrane Permeability,
pubmed-meshheading:6165739-Cyclic AMP,
pubmed-meshheading:6165739-Female,
pubmed-meshheading:6165739-Kallikreins,
pubmed-meshheading:6165739-Kinins,
pubmed-meshheading:6165739-Urea,
pubmed-meshheading:6165739-Urinary Bladder,
pubmed-meshheading:6165739-Vasopressins,
pubmed-meshheading:6165739-Water
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pubmed:year |
1981
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pubmed:articleTitle |
Role of the endogenous kallikrein-kinin system in modulating vasopressin-stimulated water flow and urea permeability in the toad urinary bladder.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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