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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-8-10
|
| pubmed:abstractText |
The isolation and propagation of functional antigen-specific lines of T lymphoblasts is described. These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype. Intravenous inoculation of a T cell reactive only against myelin basic protein led to development of clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as antigen specificity using T cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
195-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6165588-Animals,
pubmed-meshheading:6165588-Cell Line,
pubmed-meshheading:6165588-Clone Cells,
pubmed-meshheading:6165588-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:6165588-Epitopes,
pubmed-meshheading:6165588-Major Histocompatibility Complex,
pubmed-meshheading:6165588-Rats,
pubmed-meshheading:6165588-T-Lymphocytes
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|