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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-7-23
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pubmed:abstractText |
By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregion are different manifestations associated with same product. These studies utilized the I-Ab mutant mouse B6.C-H-2bm (bm12), whose defect in the normal expression of the cell surface products of the I-Ab subregion can be partially circumvented through trans-complementation by deriving hybrids between bm12 and mice expressing normal I-A subregion products. Such mice [e.g., (bm12 X B10.A)F1] express several serologically normal I-Ab products but have defects in certain I-A subregion gene products normally expressed on cells of H-2a X H-2b heterozygote mice that are used as restricting elements for antigen recognition by antigen-reactive T cell clones or recognized as alloantigens by alloreactive T cell clones. This defect in cell surface expression of certain normal I-Ab products on the mutant bm12 cells has allowed us to suggest that there exist trans-complementing products on H-2a X H-2b heterozygote mice consisting of Ab alpha Ak beta and Ak alpha Ab beta that restrict antigen recognition by cloned T cells, stimulate MLR responses by cloned T cells, and react with certain anti-Ia antisera.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-100572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-105077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-1084902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-159937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-4547437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-59980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-6157103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-6158477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-6158546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-6158548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-6777296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-7359084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-7374785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-75166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-93286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6165020-97668
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1853-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6165020-Animals,
pubmed-meshheading:6165020-Antigens, Surface,
pubmed-meshheading:6165020-Clone Cells,
pubmed-meshheading:6165020-Crosses, Genetic,
pubmed-meshheading:6165020-Cytotoxicity, Immunologic,
pubmed-meshheading:6165020-Epitopes,
pubmed-meshheading:6165020-Female,
pubmed-meshheading:6165020-Genes,
pubmed-meshheading:6165020-Genetic Complementation Test,
pubmed-meshheading:6165020-Histocompatibility Antigens Class II,
pubmed-meshheading:6165020-Major Histocompatibility Complex,
pubmed-meshheading:6165020-Male,
pubmed-meshheading:6165020-Mice,
pubmed-meshheading:6165020-Mutation,
pubmed-meshheading:6165020-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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