pubmed-article:6163723 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0025922 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1521751 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0036315 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
pubmed-article:6163723 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
pubmed-article:6163723 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:6163723 | pubmed:dateCreated | 1981-6-23 | lld:pubmed |
pubmed-article:6163723 | pubmed:abstractText | Splenic lymphocyte blastogenic responses to mitogens and antigens were compared in Schistosoma mansoni-infected C57BL/6 and CBA mice. At 1 and 2 weeks of infection, elevated responses to phytohemagglutinin (PHA) were noted in C57BL/6, but not in CBA cultures. During the same period, elevated responses to lipopolysaccharide were observed in cultures from CBA, but not from C57BL/6 mice. Responses to both mitogens were depressed in both strains later in infection. The magnitude of antigen-specific responses was greater in CBA than in C57BL/6 cultures. A cercarial extract (CE) induced significant suppressor cell activity in normal C57BL/6 cell cultures as assessed by inhibition of syngeneic cell responsiveness to PHA. CE did not induce suppressive activity in CBA cultures. CE-induced suppression was unaffected by adherent cell removal, but was sensitive to anti-Thy 1.2 plus complement treatment. CE also directly inhibited PHA-stimulated C57BL/6 cell cultures, but enhanced cultures of CBA mice. The significance of these findings is discussed in relation to the relative strain differences seen in antigen-specific lymphocyte proliferation and the levels of protection induced after immunization with irradiated cercariae. | lld:pubmed |
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pubmed-article:6163723 | pubmed:language | eng | lld:pubmed |
pubmed-article:6163723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6163723 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6163723 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6163723 | pubmed:month | Apr | lld:pubmed |
pubmed-article:6163723 | pubmed:issn | 0019-9567 | lld:pubmed |
pubmed-article:6163723 | pubmed:author | pubmed-author:WilsonE MEM | lld:pubmed |
pubmed-article:6163723 | pubmed:author | pubmed-author:LewisF AFA | lld:pubmed |
pubmed-article:6163723 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6163723 | pubmed:volume | 32 | lld:pubmed |
pubmed-article:6163723 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6163723 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6163723 | pubmed:pagination | 260-7 | lld:pubmed |
pubmed-article:6163723 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:6163723 | pubmed:year | 1981 | lld:pubmed |
pubmed-article:6163723 | pubmed:articleTitle | Strain differences in lymphocyte responses and in vitro suppressor cell induction between Schistosoma mansoni-infected C57BL/6 and CBA mice. | lld:pubmed |
pubmed-article:6163723 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6163723 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:6163723 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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