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rdf:type |
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lifeskim:mentions |
umls-concept:C0024264,
umls-concept:C0025922,
umls-concept:C0036315,
umls-concept:C0038856,
umls-concept:C0080194,
umls-concept:C0205263,
umls-concept:C0871261,
umls-concept:C1521751,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1981-6-23
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pubmed:abstractText |
Splenic lymphocyte blastogenic responses to mitogens and antigens were compared in Schistosoma mansoni-infected C57BL/6 and CBA mice. At 1 and 2 weeks of infection, elevated responses to phytohemagglutinin (PHA) were noted in C57BL/6, but not in CBA cultures. During the same period, elevated responses to lipopolysaccharide were observed in cultures from CBA, but not from C57BL/6 mice. Responses to both mitogens were depressed in both strains later in infection. The magnitude of antigen-specific responses was greater in CBA than in C57BL/6 cultures. A cercarial extract (CE) induced significant suppressor cell activity in normal C57BL/6 cell cultures as assessed by inhibition of syngeneic cell responsiveness to PHA. CE did not induce suppressive activity in CBA cultures. CE-induced suppression was unaffected by adherent cell removal, but was sensitive to anti-Thy 1.2 plus complement treatment. CE also directly inhibited PHA-stimulated C57BL/6 cell cultures, but enhanced cultures of CBA mice. The significance of these findings is discussed in relation to the relative strain differences seen in antigen-specific lymphocyte proliferation and the levels of protection induced after immunization with irradiated cercariae.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-1084329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-131175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-147295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-152792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-158432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-300294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-312841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-312843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-313956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-314479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-329699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-333963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-344795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-379213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-4153315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-4415690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-4553851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-4857865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-512747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-512780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-5535626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-565288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-565381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-571889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-677367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-6965665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-709912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-7406109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-7419296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-87433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-90093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-923634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6163723-942994
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6163723-Animals,
pubmed-meshheading:6163723-Antigens,
pubmed-meshheading:6163723-Antilymphocyte Serum,
pubmed-meshheading:6163723-Complement System Proteins,
pubmed-meshheading:6163723-DNA,
pubmed-meshheading:6163723-Epitopes,
pubmed-meshheading:6163723-Female,
pubmed-meshheading:6163723-Lipopolysaccharides,
pubmed-meshheading:6163723-Lymphocyte Activation,
pubmed-meshheading:6163723-Mice,
pubmed-meshheading:6163723-Mice, Inbred C57BL,
pubmed-meshheading:6163723-Mice, Inbred CBA,
pubmed-meshheading:6163723-Phytohemagglutinins,
pubmed-meshheading:6163723-Rabbits,
pubmed-meshheading:6163723-Schistosomiasis,
pubmed-meshheading:6163723-T-Lymphocytes, Regulatory
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pubmed:year |
1981
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pubmed:articleTitle |
Strain differences in lymphocyte responses and in vitro suppressor cell induction between Schistosoma mansoni-infected C57BL/6 and CBA mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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