| pubmed-article:6163084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C1305923 | lld:lifeskim |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:6163084 | lifeskim:mentions | umls-concept:C0025938 | lld:lifeskim |
| pubmed-article:6163084 | pubmed:issue | 5801 | lld:pubmed |
| pubmed-article:6163084 | pubmed:dateCreated | 1981-5-13 | lld:pubmed |
| pubmed-article:6163084 | pubmed:abstractText | The immunoprophylaxis of hepatitis B is hampered by the lack of a technique for growing hepatitis B virus (HBV) in tissue culture. Plasma from persistently infected individuals, one source of viral antigen, contains characteristic 22-nm spherical particles which share a common antigen (the hepatitis B surface antigen or HBsAg) with the outer envelope of the 42-nm double-shelled DNA virus. Highly purified inactivated 22-nm particles have been shown to be safe and to confer protective immunity against HBV in a recent large-scale clinical trial. We have already described the extraction from the particles of a complex of two proteins which are antigenic determinants of HBV--the polypeptide with molecular weight (MW) between 22,000 and 24,000 (called p23) and the glycosylated polypeptide (called gp28) with MW in the range 26,000--29,000 which is thought to be the glycosylated form of p23. We now report the preparation from this complex of water-soluble protein micelles which may be a suitable basis for a second-generation hepatitis B vaccine. | lld:pubmed |
| pubmed-article:6163084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6163084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6163084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6163084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6163084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6163084 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6163084 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6163084 | pubmed:author | pubmed-author:ZuckermanA... | lld:pubmed |
| pubmed-article:6163084 | pubmed:author | pubmed-author:HowardC RCR | lld:pubmed |
| pubmed-article:6163084 | pubmed:author | pubmed-author:SkellyJJ | lld:pubmed |
| pubmed-article:6163084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6163084 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:6163084 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:6163084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6163084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6163084 | pubmed:pagination | 51-4 | lld:pubmed |
| pubmed-article:6163084 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6163084 | pubmed:meshHeading | pubmed-meshheading:6163084-... | lld:pubmed |
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| pubmed-article:6163084 | pubmed:meshHeading | pubmed-meshheading:6163084-... | lld:pubmed |
| pubmed-article:6163084 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6163084 | pubmed:articleTitle | Hepatitis B polypeptide vaccine preparation in micelle form. | lld:pubmed |
| pubmed-article:6163084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6163084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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