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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5801
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pubmed:dateCreated |
1981-5-13
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pubmed:abstractText |
The immunoprophylaxis of hepatitis B is hampered by the lack of a technique for growing hepatitis B virus (HBV) in tissue culture. Plasma from persistently infected individuals, one source of viral antigen, contains characteristic 22-nm spherical particles which share a common antigen (the hepatitis B surface antigen or HBsAg) with the outer envelope of the 42-nm double-shelled DNA virus. Highly purified inactivated 22-nm particles have been shown to be safe and to confer protective immunity against HBV in a recent large-scale clinical trial. We have already described the extraction from the particles of a complex of two proteins which are antigenic determinants of HBV--the polypeptide with molecular weight (MW) between 22,000 and 24,000 (called p23) and the glycosylated polypeptide (called gp28) with MW in the range 26,000--29,000 which is thought to be the glycosylated form of p23. We now report the preparation from this complex of water-soluble protein micelles which may be a suitable basis for a second-generation hepatitis B vaccine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Micelles,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6163084-Animals,
pubmed-meshheading:6163084-Centrifugation, Density Gradient,
pubmed-meshheading:6163084-Chromatography, Affinity,
pubmed-meshheading:6163084-Epitopes,
pubmed-meshheading:6163084-Hepatitis B Surface Antigens,
pubmed-meshheading:6163084-Humans,
pubmed-meshheading:6163084-Mice,
pubmed-meshheading:6163084-Micelles,
pubmed-meshheading:6163084-Peptides,
pubmed-meshheading:6163084-Plasma,
pubmed-meshheading:6163084-Polyethylene Glycols,
pubmed-meshheading:6163084-Vaccines
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pubmed:year |
1981
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pubmed:articleTitle |
Hepatitis B polypeptide vaccine preparation in micelle form.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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