Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
|
pubmed:dateCreated |
1981-5-21
|
pubmed:abstractText |
Mice printed i.v. wit 10(9) sheep red blood cells (SRBC) produce antigen-specific T suppressor (Ts) cells which inhibit both the induction and the expression of delayed-type hypersensitivity (DTH). These Ts cells are detectable in the spleen and lymph nodes 3-5 days after priming but are largely absent by 6 days. The transient detectability of the Ts cells contrasts sharply with the profound antigen-specific suppression which persists in primed donor mice for at least a year. Evidence is presented that this long-term impairment of DTH is maintained, at least in part, by memory Ts cells which are Thy-1+, cyclophosphamide-resistant and antigen-specific. Although they appear to be co-induced with the short-lived primary Ts cells and localize initially in the lymphoid organs, they are present in the long-lived circulating pool of T cells and can be adoptively transferred by celomic parabiosis. Memory Ts cells are readily reactivated by lower doses of SRBC which would induce T effector cells rather than Ts cells in naive animals. Reactivated memory Ts cells seem to generate a population of antigen-specific secondary Ts cells which again localizes in the lymphoid organs and can adoptively suppress the induction and expression of DTH to SRBC.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0014-2980
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
937-43
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:6162649-Animals,
pubmed-meshheading:6162649-Antilymphocyte Serum,
pubmed-meshheading:6162649-Chickens,
pubmed-meshheading:6162649-Cyclophosphamide,
pubmed-meshheading:6162649-Epitopes,
pubmed-meshheading:6162649-Erythrocytes,
pubmed-meshheading:6162649-Female,
pubmed-meshheading:6162649-Hypersensitivity, Delayed,
pubmed-meshheading:6162649-Immunization, Passive,
pubmed-meshheading:6162649-Immunologic Memory,
pubmed-meshheading:6162649-Male,
pubmed-meshheading:6162649-Mice,
pubmed-meshheading:6162649-Mice, Inbred CBA,
pubmed-meshheading:6162649-Parabiosis,
pubmed-meshheading:6162649-Sheep,
pubmed-meshheading:6162649-T-Lymphocytes,
pubmed-meshheading:6162649-T-Lymphocytes, Regulatory
|
pubmed:year |
1980
|
pubmed:articleTitle |
Regulation of delayed-type hypersensitivity. V. Suppressor cell memory in antigen-specific suppression of delayed-type hypersensitivity to sheep erythrocytes.
|
pubmed:publicationType |
Journal Article
|