|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4489
|
|
pubmed:dateCreated |
1981-4-24
|
|
pubmed:abstractText |
Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
211
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1441-4
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6162200-African Continental Ancestry Group,
pubmed-meshheading:6162200-Anemia, Sickle Cell,
pubmed-meshheading:6162200-Erythropoiesis,
pubmed-meshheading:6162200-Female,
pubmed-meshheading:6162200-Fetal Hemoglobin,
pubmed-meshheading:6162200-Gene Expression Regulation,
pubmed-meshheading:6162200-Gene Frequency,
pubmed-meshheading:6162200-Genetic Linkage,
pubmed-meshheading:6162200-Hemoglobin, Sickle,
pubmed-meshheading:6162200-Humans,
pubmed-meshheading:6162200-Male,
pubmed-meshheading:6162200-Polymorphism, Genetic,
pubmed-meshheading:6162200-Reticulocytes,
pubmed-meshheading:6162200-Saudi Arabia,
pubmed-meshheading:6162200-Sickle Cell Trait,
pubmed-meshheading:6162200-United States
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
