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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1981-2-19
|
pubmed:abstractText |
Bone marrow cells from children with lymphoblastic leukemia, myeloblastic leukemia and non-Hodgkin's lymphoma were incubated with tritium-labelled methotrexate in short-term cultures. Cells obtained both during disease activity as well as during remission synthesized large quantities of methotrexate polyglutamates. Synthesis was time- and dose-dependent and occurred with concentrations of methotrexate regularly achieved during conventional treatment with this drug.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0379-8305
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
40-6
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6160026-Bone Marrow,
pubmed-meshheading:6160026-Cells, Cultured,
pubmed-meshheading:6160026-Child,
pubmed-meshheading:6160026-Dose-Response Relationship, Drug,
pubmed-meshheading:6160026-Humans,
pubmed-meshheading:6160026-Leukemia,
pubmed-meshheading:6160026-Lymphoma,
pubmed-meshheading:6160026-Methotrexate,
pubmed-meshheading:6160026-Peptide Biosynthesis,
pubmed-meshheading:6160026-Polyglutamic Acid,
pubmed-meshheading:6160026-Time Factors
|
pubmed:year |
1980
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pubmed:articleTitle |
Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|