Linked Life Data

6159864

Source:http://linkedlifedata.com/resource/pubmed/id/6159864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-1-26
pubmed:abstractText
Doses of 50 mg/kg, 100 mg/kg, and 400 mg/kg of Gamma-Falisan-Universal dry dressing agent (active ingredients including 20 per cent of Lindan and 2.5 per cent of phenyl-mercury acetate) were administered in agar suspension by stomach intubation to rats over 13 weeks, with five applications weekly. The following changes were produced: retardation in body weight, lymphopenia and leucopenia, rise of segment-nuclear neutrophils in peripheral blood, decrease of haematocrit and haemoglobin, as well as rise in activities of leucine aminopeptidase and serum glutamate oxalo-acetate transaminase. The males proved to be more sensitive in the context of their haematological parameters, while the females displayed higher sensitivity in terms of clinico-chemical values. Absolute weight increases were recorded from kidneys and liver of both males and females and from the adrenal gland of females, while weight loss was recorded from the pituitary gland of males. Changes of the same kind were expressed even more strongly, in the context of relative weights of organs. Histopathological changes were recorded from liver, kidneys, and adrenal gland of either sex, and they were histometrically confirmed. Retardation in body weight, rise in activity of leucine aminopeptidase, and weight changes of various organs were significant up to first dosage group. Analogous findings were obtained with regard to microscopic changes in kidneys. Hence, no-effect levels did not occur at all throughout the experiment.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-9055
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
[Subchronic toxicity of gamma-Falisan-Universal dry dressing agent to rats].
pubmed:publicationType
Journal Article, English Abstract