|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1981-1-29
|
|
pubmed:abstractText |
The angiotensin substrate analog Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys has no significant effect on blood pressure in sodium-replete monkeys (Macaca fascicularis) but blocks the pressor response to infused human renin. Pressor responses to angiotensin I and angiotensin II are not attenuated. In five studies in sodium-depleted monkeys, an infusion of 2 mg of the peptide per kg of body weight resulted in a reduction of mean arterial pressure (MAP) from 105 +/- 4 to 79 +/- 3 mm Hg, which is not significantly different from the response to 1 mg of the angiotensin I-converting enzyme inhibitor teprotide per kg. In uninephrectomized monkeys, inflation of a suprarenal aortic cuff caused an increase in MAP from 107 +/- 3 to 131 +/- 3 mm Hg. Infusion of 0.6 mg of the renin-inhibitory peptide per kg was followed by a return of blood pressure to 107 +/- 4 mm Hg--a depressor response similar to that observed with teprotide. This specific in vivo inhibitor of renin can now be applied to a wide variety of physiologic studies.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-167593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-185095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-191908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-200262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-233366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-240395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-282046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-36828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-4311082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-4334402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-4338182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-4350930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-4369767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-510563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159648-6986653
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5476-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6159648-Angiotensin I,
pubmed-meshheading:6159648-Angiotensin II,
pubmed-meshheading:6159648-Angiotensinogen,
pubmed-meshheading:6159648-Animals,
pubmed-meshheading:6159648-Blood Pressure,
pubmed-meshheading:6159648-Hypertension,
pubmed-meshheading:6159648-Macaca fascicularis,
pubmed-meshheading:6159648-Male,
pubmed-meshheading:6159648-Oligopeptides,
pubmed-meshheading:6159648-Peptidyl-Dipeptidase A,
pubmed-meshheading:6159648-Renin,
pubmed-meshheading:6159648-Sodium,
pubmed-meshheading:6159648-Teprotide
|
|
pubmed:year |
1980
|
|
pubmed:articleTitle |
Specific inhibition of renin by an angiotensinogen analog: studies in sodium depletion and renin-dependent hypertension.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
