rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0018894,
umls-concept:C0019627,
umls-concept:C0032659,
umls-concept:C0039194,
umls-concept:C0333668,
umls-concept:C0334094,
umls-concept:C0441655,
umls-concept:C0936012,
umls-concept:C1514873,
umls-concept:C2347338
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pubmed:issue |
5
|
pubmed:dateCreated |
1981-1-26
|
pubmed:abstractText |
T cell populations were prepared from donors immunized with hapten-carrier conjugates and were depleted of alloreactive cells by negative selection. This was accomplished by injection of the cells into H-2-disparate irradiated recipients and recovery from the thoracic duct after 18-40 h. The genetic requirements for the proliferative and helper activity of these populations was determined. The proliferative response to antigen presented on adherent, Thy-1-negative cells was determined, and a requirement for syngeneic antigen-presenting cells (APC) was demonstrated. The same T cells were assayed for their ability to give help to hapten primed B cells. It was shown that there was a requirement for syngeneic APC and for linked recognition of hapten and carrier determinants on the same molecule by the B cell and T cell. There was no requirement for the B cell to be H-2 compatible with the T cell. The requirement for linked recognition was taken as evidence that the responses in allogeneic combinations were not a result of positive allogeneic effects. Precisely comparable restrictions were found with positively selected cells.
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pubmed:grant |
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-102721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-1078737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-1087330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-109564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-112037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-304458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-306407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-306408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-320663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-325144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-4122709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-4126770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-415110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-51901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-52686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-6153679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-70468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-75242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-811749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-92522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-956724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-96182
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0022-1007
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
152
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1311-28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6159449-Animals,
pubmed-meshheading:6159449-B-Lymphocytes,
pubmed-meshheading:6159449-Epitopes,
pubmed-meshheading:6159449-Isoantigens,
pubmed-meshheading:6159449-Major Histocompatibility Complex,
pubmed-meshheading:6159449-Mice,
pubmed-meshheading:6159449-Mice, Inbred Strains,
pubmed-meshheading:6159449-Selection, Genetic,
pubmed-meshheading:6159449-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|