Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-1-26
pubmed:abstractText
T cell populations were prepared from donors immunized with hapten-carrier conjugates and were depleted of alloreactive cells by negative selection. This was accomplished by injection of the cells into H-2-disparate irradiated recipients and recovery from the thoracic duct after 18-40 h. The genetic requirements for the proliferative and helper activity of these populations was determined. The proliferative response to antigen presented on adherent, Thy-1-negative cells was determined, and a requirement for syngeneic antigen-presenting cells (APC) was demonstrated. The same T cells were assayed for their ability to give help to hapten primed B cells. It was shown that there was a requirement for syngeneic APC and for linked recognition of hapten and carrier determinants on the same molecule by the B cell and T cell. There was no requirement for the B cell to be H-2 compatible with the T cell. The requirement for linked recognition was taken as evidence that the responses in allogeneic combinations were not a result of positive allogeneic effects. Precisely comparable restrictions were found with positively selected cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-102721, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-1078737, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-1087330, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-109564, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-112037, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-304458, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-306407, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-306408, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-320663, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-325144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-4122709, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-4126770, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-415110, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-51901, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-52686, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-5355110, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-6153679, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-70468, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-75242, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-811749, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83698, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83701, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-83702, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-92522, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-956724, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159449-96182
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1311-28
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't