Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-1-29
pubmed:abstractText
1 Eleven analogues of sodium cromoglycate have been tested for their ability to suppress histamine release induced by anti-IgE from passively sensitized human lung fragments in vitro. 2 With the exception of WY 16922, which released histamine at high concentrations, all inhibited histamine release in a linear dose-related manner. 3 The analogues were 30 to 1500 times more potent than sodium cromoglycate. However, their regression slopes of activity upon log-concentration were only one-third as steep as that for sodium cromoglycate, indicating a possible difference in their mechanism of action. 4 In comparison with sodium cromoglycate, the analogues were more potent in human lung than in rat passive cutaneous anaphylaxis (PCA); there was no quantitative correlation between potencies in the two tests. 5 The human lung model is not predictive of anti-asthmatic activity in man as the six analogues tested clinically are less effective than sodium cromoglycate. 6 These results throw doubt on the use of models of mast cell degranulation in the search for anti-allergic drugs and, possibly, on the relative importance of mast cell degranulation in the pathogenesis of asthma.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-104761, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-105825, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-25634, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4099491, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4121709, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4138541, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4199408, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4212341, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4306785, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-4596403, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-48393, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-48779, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-58988, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-64936, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-668102, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-73514, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-78665, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-824068, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-82898, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-837962, http://linkedlifedata.com/resource/pubmed/commentcorrection/6159030-930755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The activity of sodium cromoglycate analogues in human lung in vitro: a comparison with rat passive cutaneous anaphylaxis and clinical efficacy.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro