| pubmed-article:6158548 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:6158548 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:6158548 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6158548 | pubmed:dateCreated | 1980-12-16 | lld:pubmed |
| pubmed-article:6158548 | pubmed:abstractText | Studies in our laboratory and elsewhere have shown that it is possible to propagate antigen-specific murine T cells in vitro with resultant specific stepwise enrichment of antigen-induced proliferative cells. The proliferative responses of these T cells are antigen specific and dependent upon the presence of antigen-presenting cells (spleen cells) that share the I-A subregion with the proliferating T cell. Using techniques of soft-agar cloning, it has been further possible to isolate clones of antigen-reactive T lymphocytes from such long-term cultures. Data suggesting that these were clones of antigen-reactive T cells were obtained by studying the recognition of antigen in association with antigen-presenting cells with a panel of such clones of antigen-reactive T cells. Proof of clonality was obtained by subcloning. Clones derived from F1-immune mice can be divided into three separate categories: one clone recognizes antigen in association with antigen-presenting determinants of parent A and the F1; the second type recognizes antigen in association with antigen-presenting determinants of parent B and the F1; and the third type recognizes antigen only in association with antigen-presenting determinants of the F1 mouse. Genetic studies on the major histocompatibility complex requirements for antigen presentation to such F1-reactive T cell clones suggests that the hybrid antigen-presenting determinant in this system results from transcomplementation of products of the I-A region of haplotypes a and b. These studies support the concept developed in our laboratory that there exist unique F1 hybrid determinants on (A/J X C57BL/6) F1 cells and suggest that these determinants can be utilized physiologically by hybrid mice in immunocompetent cellular interactions. | lld:pubmed |
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| pubmed-article:6158548 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6158548 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6158548 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6158548 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6158548 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6158548 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6158548 | pubmed:author | pubmed-author:FathmanC GCG | lld:pubmed |
| pubmed-article:6158548 | pubmed:author | pubmed-author:KimotoMM | lld:pubmed |
| pubmed-article:6158548 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6158548 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6158548 | pubmed:volume | 152 | lld:pubmed |
| pubmed-article:6158548 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6158548 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6158548 | pubmed:pagination | 759-70 | lld:pubmed |
| pubmed-article:6158548 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6158548 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6158548 | pubmed:articleTitle | Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. | lld:pubmed |
| pubmed-article:6158548 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6158548 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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