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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1980-11-24
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pubmed:abstractText |
Human tumors implanted subcutaneously into athymic mice produced human beta 2-microglobulin which was readily identified and quantified in mouse plasma. Implanted solid tumors of the lines Clouser, SW480, Hep-2, Capan-1, and HT-29 released amounts of beta 2-microglobulin directly related to tumor mass. The extractable beta 2-microglobulin per gram of tumor was constant for each cell line, but there was a 100-fold variation between the lines. In general, the plasma level of beta 2-microglobulin correlated with the amount of free beta 2-microglobulin extracted from each tumor. From these observations it can be concluded that the variablility observed in the circulating levels of beta 2-microglobulin among cancer patients is related to the beta 2-microglobulin content of the tumor and the total tumor mass.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0304-3568
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-38
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6157586-Animals,
pubmed-meshheading:6157586-Beta-Globulins,
pubmed-meshheading:6157586-Female,
pubmed-meshheading:6157586-Humans,
pubmed-meshheading:6157586-Kidney,
pubmed-meshheading:6157586-Liver,
pubmed-meshheading:6157586-Mice,
pubmed-meshheading:6157586-Mice, Nude,
pubmed-meshheading:6157586-Neoplasm Transplantation,
pubmed-meshheading:6157586-Neoplasms,
pubmed-meshheading:6157586-Spleen,
pubmed-meshheading:6157586-Transplantation, Heterologous,
pubmed-meshheading:6157586-beta 2-Microglobulin
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pubmed:year |
1980
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pubmed:articleTitle |
Release of beta 2-microglobulin by human tumors grown in nude mice.
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pubmed:publicationType |
Journal Article
|