Linked Life Data

6157571

Source:http://linkedlifedata.com/resource/pubmed/id/6157571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1980-11-20
pubmed:abstractText
Incubation of neuronal cell bodies in a calcium-free medium depresses the amount, but not the rate, of fast axonal transport of [3H]protein. Under these conditions, which do not affect protein synthesis or general energy metabolism, less protein appears to be loaded onto the transport system. Depression of transport also is seen when cell bodies are exposed to medium containing Co2+; selective exposure of axons to this medium has no effect on transport. These findings have led to the concept of an initiation phase of fast axonal transport that comprises the events by which selected proteins are transferred from their polysomal sites of synthesis to the transport system. The divalent cation specificity of the Ca2+ requirement, and its occurrence subsequent to Golgi apparatus-associated glycosylation, suggest that proteins destined for fast axonal transport are routed through the soma in a manner similar to that of secretory proteins and integral membrane proteins in nonneural cells. This analogy is pursued to consider a scheme whereby Golgi-derived vesicles deliver fast-transported proteins to the axonal smooth endoplasmic reticulum. Possible roles of Ca2+ in the formation and exocytotic fusion of such vesicles are considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-9446
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2809-14
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The role of calcium in the initiation of fast axonal transport.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.