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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1980-10-21
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pubmed:abstractText |
The studies reported here were designed to evaluate the potential contribution of interferon (IF) to the biological activities mediated by allogeneic effect factor (AEF), a soluble product of allogeneic cell interactions, on responses of T and B lymphocytes. AEF supernatants were found to contain varying levels of IF, predominantly of type II (immune). AEF preparations which were practically free of--or very low in--IF activity were obtained by bovine serum albumin-Sepharose chromatography of AEF, or by using strain combinations involving K-only or I-only differences within the H-2 complex for the production of AEF. Such preparations retained their biological activities in three in vitro assays characteristic of AEF: (a) induction of primary self-H-2-reactive cytotoxic T-lymphocyte responses, (b) mitogenicity for normal T cells, and (c) induction of plaque-forming cell antibody responses to a T-dependent antigen in T-cell-depleted spleen cultures. These results demonstrate that IF does not play any significant role in the biological activities medicated by AEF.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-4910
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
131C
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-47
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6157348-Animals,
pubmed-meshheading:6157348-B-Lymphocytes,
pubmed-meshheading:6157348-Cell Division,
pubmed-meshheading:6157348-Cells, Cultured,
pubmed-meshheading:6157348-Hemolytic Plaque Technique,
pubmed-meshheading:6157348-Interferons,
pubmed-meshheading:6157348-Isoantigens,
pubmed-meshheading:6157348-Lymphocytes,
pubmed-meshheading:6157348-Lymphokines,
pubmed-meshheading:6157348-Mice,
pubmed-meshheading:6157348-Mice, Inbred Strains,
pubmed-meshheading:6157348-Spleen,
pubmed-meshheading:6157348-T-Lymphocytes
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pubmed:articleTitle |
The biological effects of allogeneic effect factor (AEF) on T lymphocytes. III.--Interferon does not contribute to the biological activities displayed by AEF on both T and B lymphocytes.
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pubmed:publicationType |
Journal Article
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