|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007582,
umls-concept:C0018894,
umls-concept:C0025255,
umls-concept:C0030685,
umls-concept:C0039195,
umls-concept:C0127400,
umls-concept:C0205263,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0750540,
umls-concept:C0871261,
umls-concept:C1283071,
umls-concept:C1363844,
umls-concept:C1533691,
umls-concept:C1552861,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1963578,
umls-concept:C2911692
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1980-10-27
|
|
pubmed:abstractText |
T helper cell induction and the specificity of T cell-mediated help as generated during alloreactive and H-2-restricted, virus- or hapten-specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double-chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H-2-restricted T cell responses, antigen-specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell-impermeable membrane via soluble products in an apparently nonspecific and nonrestricted manner. The data suggest that similar rules govern T-T cell interactions in alloreactive and H-2-restricted CTL responses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
577-82
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:6156847-Animals,
pubmed-meshheading:6156847-Cell Membrane Permeability,
pubmed-meshheading:6156847-Cytotoxicity, Immunologic,
pubmed-meshheading:6156847-Epitopes,
pubmed-meshheading:6156847-H-2 Antigens,
pubmed-meshheading:6156847-Isoantigens,
pubmed-meshheading:6156847-Lymphocyte Cooperation,
pubmed-meshheading:6156847-Mice,
pubmed-meshheading:6156847-Mice, Inbred BALB C,
pubmed-meshheading:6156847-Mice, Inbred C57BL,
pubmed-meshheading:6156847-Mice, Inbred CBA,
pubmed-meshheading:6156847-Parainfluenza Virus 1, Human,
pubmed-meshheading:6156847-Solubility,
pubmed-meshheading:6156847-T-Lymphocytes,
pubmed-meshheading:6156847-Trinitrobenzenes
|
|
pubmed:year |
1980
|
|
pubmed:articleTitle |
T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted cytotoxic T lymphocyte responses across cell-impermeable membranes.
|
|
pubmed:publicationType |
Journal Article
|
