Linked Life Data

6155966

Source:http://linkedlifedata.com/resource/pubmed/id/6155966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-9-23
pubmed:abstractText
In thirteen cases of senile dementia of the Alzheimer type severe loss of nerve cells from the locus caeruleus was frequently seen together with reductions in nucleolar volume and cytoplasmic RNA in surviving cells, averaging 14 and 21 per cent respectively. These histological findings were matched in two cases by biochemical measurements of loss of noradrenaline from all brain regions examined, ranging from 10 per cent in temporal cortex to 53 per cent in hypothalamus. By contrast, neither nucleolar volume nor cytoplasmic RNA was altered in cells of the substantia nigra, nor was dopamine content significantly altered in most regions. In vascular dementia neither noradrenaline nor dopamine metabolism was changed except in regions of local circulatory deficiency. These findings provide evidence of a primary degeneration of the noradrenergic system in Alzheimer type dementia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1250
pubmed:author
pubmed:issnType
Print
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-41
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Changes in the monoamine containing neurones of the human CNS in senile dementia.
pubmed:publicationType
Journal Article