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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Pt 2
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pubmed:dateCreated |
1980-8-28
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pubmed:abstractText |
Effects of dimaprit and 4-methylhistamine, two histamine H2-receptor agonists, on noradrenaline and serotonin systems in the rat brain were investigated. Administration of dimaprit into the lateral brain ventricle produced 30% decrease in hypothalamal noradrenaline. 2 h after administration of dimaprit the level of 3-methoxy-4-hydroxyphenylglycol was increased by 50%. 4-Methylhistamine and histamine produced qualitatively the same effects as dimaprit. Dimaprit and 4-methylhistamine increased locomotor activity in tranylcypromine-treated rats. The hyperkinetic action of both drugs was prevented by phenoxybenzamine. Dimaprit had negligible effect on the serotonin system while 4-methylhistamine and histamine decreased serotonin and simultaneously increased 5-hydroxyindolcacetic acid. 4-Methylhistamine and histamine, but not dimaprit, evoked head-twitches in tranylcypromine-treated rats. It is concluded that dimaprit and 4-methylhistamine act similarly on the noradrenaline system, probably releasing noradrenaline, but having different effects on the serotonin system. 4-Methylhistamine (and histamine) probably releases serotonin from rat hypothalamus while dimaprit does not. The results are discussed in relation to a possible interaction of histamine with both noradrenaline and serotonin systems in the rat brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-methylhistamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dimaprit,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxyhydroxyphenylglycol,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhistamines,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Thiourea,
http://linkedlifedata.com/resource/pubmed/chemical/Tranylcypromine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0065-4299
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-72
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6155770-Animals,
pubmed-meshheading:6155770-Behavior, Animal,
pubmed-meshheading:6155770-Brain,
pubmed-meshheading:6155770-Dimaprit,
pubmed-meshheading:6155770-Female,
pubmed-meshheading:6155770-Histamine,
pubmed-meshheading:6155770-Hydroxyindoleacetic Acid,
pubmed-meshheading:6155770-Methoxyhydroxyphenylglycol,
pubmed-meshheading:6155770-Methylhistamines,
pubmed-meshheading:6155770-Norepinephrine,
pubmed-meshheading:6155770-Rats,
pubmed-meshheading:6155770-Receptors, Histamine,
pubmed-meshheading:6155770-Receptors, Histamine H2,
pubmed-meshheading:6155770-Serotonin,
pubmed-meshheading:6155770-Thiourea,
pubmed-meshheading:6155770-Tranylcypromine
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pubmed:year |
1980
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pubmed:articleTitle |
Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system.
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pubmed:publicationType |
Journal Article
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