Linked Life Data

6151905

Source:http://linkedlifedata.com/resource/pubmed/id/6151905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-4-15
pubmed:abstractText
The experiments concerned the effects of beta-adrenoceptor agonists and antagonists on the leukotriene-C4 (LTC4)-induced secretory release response from carrageenan-elicited rat peritoneal macrophages. Both the non-selective beta-adrenoceptor agonist isoprenaline and the selective beta 2-adrenoceptor agonist salbutamol reversed the LTC4-induced release response. Addition of the non-selective beta-adrenoceptor antagonist sotalol or the beta 2-selective antagonist H3525 abolished these effects. Practolol, a selective beta 1-adrenoceptor antagonist was without any effect on the isoprenaline-LTC4 interaction. These results are consistent with the presence of beta 2-adrenoceptors on macrophages. The results of this study are discussed in view of a possible, cyclic adenosine 3'5'-monophosphate (cAMP)-mediated interaction between prostaglandin E2 and LTC4 in modulating macrophage function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-70
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Beta 2-adrenoceptor agonists reverse the leukotriene C4-induced release response of macrophages.
pubmed:publicationType
Journal Article