Linked Life Data

6151670

Source:http://linkedlifedata.com/resource/pubmed/id/6151670

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-3-5
pubmed:abstractText
Recently, we found that lipophilicity is a good predictor of the degree to which most peptides cross the blood-brain-barrier. Small (MW less than 1000) peptides with an N-terminal tyrosine, however, penetrated to a much smaller degree than was predicted by their measurements of lipophilicity. We show here that two such peptides, N-Tyr-MIF-1 and Met-enkephalin, can significantly inhibit transport of 125I-N-Tyr-MIF-1 out of the rat brain in vivo in a saturable, dose-dependent way. The half-time disappearance of injected 125I-N-Tyr-MIF-1 from the rat brain was 12.4 min but when injected with 200 nmol/animal of unlabeled N-Tyr-MIF-1 was 23.6 min (p less than 0.01). The Km was calculated to be 0.123 nmol. At higher doses, leucine, but not tyrosine, alanine, glutamine, MIF-1, or the dipeptide Gly-Gly, also significantly inhibited transport out of the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
943-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
A brain-to-blood carrier-mediated transport system for small, N-tyrosinated peptides.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S.