Linked Life Data

6151628

Source:http://linkedlifedata.com/resource/pubmed/id/6151628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-3-14
pubmed:abstractText
Central benzodiazepine (BZ) receptors were looked for in the spinal cord, cerebral cortex and cerebellum of the cat. Both [3H]Ro 15-1788 and [3H]flunitrazepam bound to benzodiazepine receptors with apparent dissociation constants (KD) in the nanomolar range and Hill coefficients near unity. The concentration of binding sites was much greater (10-40 times,depending on the ligand used) in the cortex and cerebellum than in the spinal cord. gamma-Aminobutyric acid (GABA) significantly reduced the KD value of the binding of tritiated flunitrazepam in all three areas of the central nervous system (CNS). The displacement of [3H]Ro 15-1788 by different benzodiazepine ligands indicates a relative prevalence of BZ1 (high affinity for beta-carboline esters and the triazolopyridazine, CL 218 872) in the cerebellum, a predominance of BZ2 (low affinity for the same agents) in the spinal cord and a mixture of both types in the cortex. The possibility that there is regional heterogeneity of receptors for benzodiazepines in CNS of the cat is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1137-40
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Central benzodiazepine receptors in the spinal cord and other regions of the CNS of the cat.
pubmed:publicationType
Journal Article