|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1985-3-5
|
|
pubmed:abstractText |
DG-5128 (2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate) at concentrations up to 10 microM inhibited [3H]clonidine binding more effectively than it did [3H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition was homogeneous and consistent with the law of simple mass action. DG-5128 exhibited a 7.4 times higher affinity (pKi = 6.28) toward alpha 2-adrenoceptors than alpha 1-adrenoceptors. The results indicate that DG-5128 is a preferential alpha 2-antagonist.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
106
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
625-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6151511-Adrenergic alpha-Antagonists,
pubmed-meshheading:6151511-Animals,
pubmed-meshheading:6151511-Cerebral Cortex,
pubmed-meshheading:6151511-Clonidine,
pubmed-meshheading:6151511-Hypoglycemic Agents,
pubmed-meshheading:6151511-Imidazoles,
pubmed-meshheading:6151511-Male,
pubmed-meshheading:6151511-Prazosin,
pubmed-meshheading:6151511-Rats,
pubmed-meshheading:6151511-Rats, Inbred Strains
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
The selectivity of DG-5128 as an alpha 2-adrenoceptor antagonist.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
