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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-2-7
|
| pubmed:abstractText |
The effects of three analogs of the brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) were tested in several behavioral tests after peripheral injection in rats. In the passive avoidance test, rats injected SC with 1 mg/kg Ala-MIF-1 or Phe-MIF-1 entered the second compartment of two-chamber shuttle box significantly faster than did rats receiving diluent. Leu-MIF-1 failed to produce significantly faster entry compared to diluent. None of the peptides significantly affected ambulation, rearing, or defecation. Flinch and escape thresholds were not affected by Ala-MIF-1, the only analog tested for this behavior. The results demonstrate that some analogs of Tyr-MIF-1 can exert behavioral effects similar to those exerted by the parent compound whereas other analogs resemble MIF-1 in being inactive under these experimental conditions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0091-3057
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
809-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1984
|
| pubmed:articleTitle |
Some analogs of Tyr-MIF-1 affect passive avoidance behavior but not motor activity in rats.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|