Linked Life Data

6151194

Source:http://linkedlifedata.com/resource/pubmed/id/6151194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-2-7
pubmed:abstractText
Evidence suggests that morphine analgesia depends on the integrity of monoaminergic transmitter systems. Some forms of stress analgesia seem to be related to morphine analgesia, while others are not. To assess whether opioid and non-opioid stress analgesia differ in their reliance on monoamine systems, the effects of parachlorophenylalanine (PCPA) and yohimbine on analgesia produced by prolonged intermittent and brief continuous footshock were examined on the hotplate test. The interaction of adrenergic and endorphinergic activity with serotonergic mechanisms following these stressors was also investigated by testing the effects of yohimbine and naloxone on rats with prior PCPA treatment. Yohimbine alone significantly reduced baseline hotplate latencies, while PCPA and naloxone did not. The two stressors differed in the effects produced by both naloxone and PCPA. Naloxone significantly reversed stress analgesia in the prolonged stress condition, but not the brief stress condition. PCPA significantly enhanced the antinociceptive effect of brief continuous shock, while leaving the response to prolonged intermittent shock unaffected. In contrast, yohimbine blocked the analgesic effects of prolonged stress. For the brief stress condition, naloxone reversed the elevated thresholds elicited in PCPA treated rats. Naloxone also reversed stress analgesia for PCPA treated rats exposed to prolonged intermittent stress. Yohimbine lowered the responses of PCPA treated rats subjected to brief continuous shock. These results support an interactive model of stress analgesia dependent upon serotonergic, adrenergic, and endorphinergic transmitter systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
681-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Stress analgesia: effects of PCPA, yohimbine, and naloxone.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't