Linked Life Data

6150234

Source:http://linkedlifedata.com/resource/pubmed/id/6150234

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8413
pubmed:dateCreated
1984-12-31
pubmed:abstractText
Frequencies of HLA A, B, C, and DR antigens were calculated in 1009 leukaemia patients, all of whom had been treated with bone-marrow transplantation and reported to the International Bone Marrow Transplant Registry. Cw3 (relative risk = 2 X 26, p = 0 X 00002) and Cw4 (relative risk = 2 X 18, p = 0 X 00003) were significantly associated with acute leukaemia (p values adjusted for multiple comparisons). Cw3 (relative risk = 2 X 97, p = 0 X 00002) and Cw4 (relative risk = 2 X 10, p = 0 X 004) were also significantly associated with acute lymphoblastic leukaemia and Cw4 was significantly associated with acute myelogenous leukaemia (relative risk = 2 X 39, p = 0 X 0003). The data suggest that Cw3 and Cw4 may be markers for leukaemia susceptibility genes, genes that code for low immune responsiveness to putative leukaemia viruses, or genes that regulate the response to chemotherapy and, therefore, the attainment of remission, since most of these patients underwent transplantation during remission.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1176-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
HLA C associations with acute leukaemia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't