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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1985-1-17
|
| pubmed:abstractText |
We have studied the effect of the intravenous administration of the following drugs on ventricular refractoriness in 35 experiments in open chested beagle dogs: atenolol 0.2 mg X kg-1; nadolol 0.05 mg X kg-1; oxprenolol 0.2 mg X kg-1; pindolol 0.04 mg X kg-1; propranolol 0.2 mg X kg-1; sotalol 0.6 mg X kg-1 and timolol 0.1 mg X kg-1. The animals were anaesthetised with chloralose and urethane. Measurements were made of left ventricular epicardial monophasic action potentials (MAP) (n = 35) and the left ventricular paced evoked response (PER) (n = 25) at a fixed paced cycle length of between 220 and 310 ms. The animals were initially beta-blocked with iv pindolol or propranolol and the drug under study then administered iv 10 min later. The results were as follows: (control and post drug administration) MAP: nadolol 151 +/- 12 SD to 172 +/- 13 SD (p less than 0.001); oxprenolol 153 +/- 21 to 178 +/- 20 (p less than 0.001); sotalol 153 +/- 19 to 176 +/- 20 (p less than 0.001); atenolol 152 +/- 25 to 153 +/- 23 (NS); pindolol 149 +/- 11 to 152 +/- 10 (NS); propranolol 152 +/- 26 to 155 +/- 26 (NS); timolol 144 +/- 23 to 144 +/- 21 (NS). PER: nadolol 172 +/- 14 to 190 +/- 20 (p less than 0.001); oxprenolol 164 +/- 16 to 188 +/- 15 (p less than 0.001); propranolol 166 +/- 22 to 173 +/- 18 (NS).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Atenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Nadolol,
http://linkedlifedata.com/resource/pubmed/chemical/Oxprenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Sotalol,
http://linkedlifedata.com/resource/pubmed/chemical/Timolol
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0008-6363
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
683-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6149809-Action Potentials,
pubmed-meshheading:6149809-Adrenergic beta-Antagonists,
pubmed-meshheading:6149809-Animals,
pubmed-meshheading:6149809-Atenolol,
pubmed-meshheading:6149809-Cardiac Pacing, Artificial,
pubmed-meshheading:6149809-Dogs,
pubmed-meshheading:6149809-Electrocardiography,
pubmed-meshheading:6149809-Female,
pubmed-meshheading:6149809-Heart,
pubmed-meshheading:6149809-Heart Ventricles,
pubmed-meshheading:6149809-Male,
pubmed-meshheading:6149809-Nadolol,
pubmed-meshheading:6149809-Oxprenolol,
pubmed-meshheading:6149809-Pindolol,
pubmed-meshheading:6149809-Propanolamines,
pubmed-meshheading:6149809-Propranolol,
pubmed-meshheading:6149809-Sotalol,
pubmed-meshheading:6149809-Timolol
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Class III action of beta-blocking agents.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|