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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1984-11-28
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pubmed:abstractText |
In animals the secretion of GH is characterized by a series of spontaneous peaks. The situation in avian species, however, is unknown. The present study examines this in the domestic fowl. Blood samples were obtained via a remote catheter at 5-min intervals from young male chickens. An episodic pattern of GH secretion was observed having an interpulse interval (frequency) of approximately 1 h. Episodic GH secretion was altered by peripheral administration of drugs which influence adrenergic function. Spontaneous GH peaks were not observed following the administration of (1) bis-(4-methyl-1-homopiperazinyl-thiocarbonyl) disulfide (FLA63) or diethyldithiocarbamate (DDC) (which blocks norepinephrine (NE) and epinephrine (E) synthesis by inhibiting dopamine-beta-hydroxylase), (2) phenoxybenzamine (an alpha 1-adrenergic antagonist) and (3) clonidine (an alpha 2-adrenergic agonist). Neither alpha-methyl-p-tyrosine, which blocks dopamine (DA), NE and E synthesis, nor yohimbine, a predominantly alpha 2-antagonist could completely suppress episodic GH secretion. These data support a role for NE/E, acting via alpha adrenergic receptors, in the control of epidosic GH secretion in the domestic fowl.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bis(4-Methyl-1-Homopiperazinylthioca...,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Ditiocarb,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltyrosines,
http://linkedlifedata.com/resource/pubmed/chemical/Phenoxybenzamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Methyltyrosine
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pubmed:status |
MEDLINE
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pubmed:issn |
0742-8413
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
409-13
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:6149089-Animals,
pubmed-meshheading:6149089-Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide,
pubmed-meshheading:6149089-Chickens,
pubmed-meshheading:6149089-Clonidine,
pubmed-meshheading:6149089-Ditiocarb,
pubmed-meshheading:6149089-Growth Hormone,
pubmed-meshheading:6149089-Male,
pubmed-meshheading:6149089-Methyltyrosines,
pubmed-meshheading:6149089-Phenoxybenzamine,
pubmed-meshheading:6149089-Receptors, Adrenergic, alpha,
pubmed-meshheading:6149089-Yohimbine,
pubmed-meshheading:6149089-alpha-Methyltyrosine
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pubmed:year |
1984
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pubmed:articleTitle |
Episodic growth hormone secretion in the domestic fowl (Gallus domesticus): alpha adrenergic regulation.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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