Linked Life Data

6148799

Source:http://linkedlifedata.com/resource/pubmed/id/6148799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-11-9
pubmed:abstractText
In a previous study (Dy et al. 1981) we have demonstrated that histamine-producing cell stimulating factor (HCSF), a lymphokine released by T-cells, is present in supernatants obtained from secondary mixed lymphocyte cultures set up with cells from the donor and the recipient of a skin allograft, and that HCSF causes an increased production of histamine from target cells present in bone marrow. The most abundant source of target cells was found in the less dense layer of a discontinuous Ficoll gradient of bone marrow cells. Ultrastructural studies of this layer showed that it is composed of four types of cell: type I, immature cells; type II, mastocyte-like cells; type III, macrophages and type IV, lymphocytes. We have examined the effect of HCSF on this cell population; in long-term cultures we observed a progressive numerical decrease in type I cells, accompanied by an increase in type II cells (clearly observed as early as 48 h), leading to a pure population of mastocytes cells after 45 days of culture.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6075
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Ultrastructural study on long-term cultures of bone marrow cells with histamine-producing stimulating factor (HCSF).
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't