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rdf:type |
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lifeskim:mentions |
umls-concept:C0003695,
umls-concept:C0024264,
umls-concept:C0042360,
umls-concept:C0443254,
umls-concept:C0679823,
umls-concept:C0870883,
umls-concept:C0871261,
umls-concept:C1444748,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1984-11-14
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pubmed:abstractText |
Normal human lymphocytes (L) (8 X 10(5) ml-1) incubated with methoxamine (Me) (1 X 10(-7) M) (Me-L) triggered the mechanical response of the isolated vas deferens of the rat. L or Me alone did not modify this contractile activity at the concentrations cited above. Me alone (10(-6) to 10(-3) M) increased the tension of the vas. In the presence of L (8 X 10(5) ml-1) the dose-response curve to Me shifted to the left and the efficacy of Me was enhanced. Inhibitors of alpha 1-adrenoceptors completely blocked the reaction between Me and L while drugs that block alpha 1 and alpha 2-adrenoceptors reduced the reaction between Me-L and the vas deferens. Direct contact of Me-L with the assay organ was not necessary. Cell-free supernatants of L exposed to Me (Me-L supernatants) elicited the reaction in the same way as Me-L. This effect required the continuous presence of Me since dialyzed Me-L supernatants were inactive. Inhibitors of lipoxygenase(s) completely blocked the positive inotropic effect of Me-L or of Me-L supernatants. Inhibitors of cyclo-oxygenase potentiated this effect. These results suggest that Me reacts with alpha 1-adrenoceptors of L. From this reaction, soluble factors are released that potentiate the alpha-adrenoceptor stimulatory effect of Me on the vas deferens as a consequence of the release of oxidative products of the lipoxygenase/s pathway of arachidonic acid.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-109510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-13996119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-16222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-164246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-27411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-4364417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-4372291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-448098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-448099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-448290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-5284360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6113148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6123396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6133206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6267618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6269923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6277335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6307564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6415490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6423019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6896092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-6983918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6148116-949493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
863-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6148116-Adrenergic alpha-Agonists,
pubmed-meshheading:6148116-Adrenergic alpha-Antagonists,
pubmed-meshheading:6148116-Animals,
pubmed-meshheading:6148116-Arachidonic Acid,
pubmed-meshheading:6148116-Arachidonic Acids,
pubmed-meshheading:6148116-Humans,
pubmed-meshheading:6148116-Lipoxygenase Inhibitors,
pubmed-meshheading:6148116-Lymphocytes,
pubmed-meshheading:6148116-Male,
pubmed-meshheading:6148116-Methoxamine,
pubmed-meshheading:6148116-Muscle, Smooth,
pubmed-meshheading:6148116-Muscle Contraction,
pubmed-meshheading:6148116-Rats,
pubmed-meshheading:6148116-Time Factors,
pubmed-meshheading:6148116-Vas Deferens
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pubmed:year |
1984
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pubmed:articleTitle |
alpha-Adrenoceptor stimulated lymphocytes trigger the mechanical response of vas deferens: participation of arachidonic acid metabolites.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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