Linked Life Data

6147940

Source:http://linkedlifedata.com/resource/pubmed/id/6147940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-10-12
pubmed:abstractText
The effect of acute beta 1-blockade (100 mg metoprolol) and beta 1/2-blockade (2 mg levobunolol) on exercise performance and metabolism was studied in 16 healthy male physical education students. The study was carried out in a randomized double blind cross-over fashion. The maximal oxygen uptake was unchanged in all conditions, but maximal exercise capacity was reduced by 4% (beta 1-blockade) and 5% (beta 1/2-blockade). Maximal lactate concentration was reduced by 10% (beta 1-blockade) and 20% (beta 1/2-blockade). In 50 min treadmill exercise with 68% of maximal exercise capacity, beta 1/2-blockade led to premature exhaustion in 50% of subjects. Moreover, blood levels of glucose decreased (in some subjects to about 2.5 mmol X 1(-1], while the values were unchanged under beta 1-blockade. Free fatty acids and glycerol were similarly reduced by both beta-blocking agents. HGH, cortisol, adrenalin, and noradrenalin increased under beta-blockade, but more under beta 1/2-blockade than under beta 1-blockade. Insulin remained unchanged as compared with the unmedicated condition. The perceived exertion was elevated under both beta-blocking agents. Conclusion: Beta 1-blockade affects exercise performance, especially endurance performance, less than beta 1/2-blockade due to unaffected beta 2-receptors mediating glycogenolysis in the skeletal muscles.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
380-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Behavior of physical endurance and metabolism during acute beta 1 and beta 1/2-blockade].
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Randomized Controlled Trial