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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1984-10-4
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pubmed:abstractText |
Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of "active resuscitation" of energy-depleted hearts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-5223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
402-10
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6147442-Adenosine Triphosphate,
pubmed-meshheading:6147442-Animals,
pubmed-meshheading:6147442-Aorta,
pubmed-meshheading:6147442-Constriction,
pubmed-meshheading:6147442-Dogs,
pubmed-meshheading:6147442-Glucose-6-Phosphate,
pubmed-meshheading:6147442-Glucosephosphates,
pubmed-meshheading:6147442-Glutamates,
pubmed-meshheading:6147442-Glutamic Acid,
pubmed-meshheading:6147442-Heart,
pubmed-meshheading:6147442-Heart Arrest, Induced,
pubmed-meshheading:6147442-Hypothermia, Induced,
pubmed-meshheading:6147442-Lactates,
pubmed-meshheading:6147442-Myocardium,
pubmed-meshheading:6147442-Oxygen Consumption,
pubmed-meshheading:6147442-Perfusion,
pubmed-meshheading:6147442-Phosphocreatine,
pubmed-meshheading:6147442-Potassium,
pubmed-meshheading:6147442-Solutions,
pubmed-meshheading:6147442-Stroke Volume
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pubmed:year |
1984
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pubmed:articleTitle |
Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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