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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-9-7
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pubmed:abstractText |
Lethargy, marked muscle weakness and rigidity, a maximal temperature of 40 degrees C, and a maximal creatine kinase value of 17,240 IU/liter developed in a 36-year-old woman following treatment with several neuroleptics. Initial treatment with dantrolene was unsuccessful. The patient's condition improved gradually over a 10-day period with no specific therapy. Muscle biopsy revealed a contracture pattern diagnostic of malignant hyperthermia susceptibility, as well as abnormal sensitivity to fluphenazine. This report may be the first description of a patient with neuroleptic malignant syndrome in whom muscle biopsy response similar to that seen in malignant hyperthermia occurred and documents that dantrolene is not uniformly successful therapy for this syndrome.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9343
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
338-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6147089-Adult,
pubmed-meshheading:6147089-Antipsychotic Agents,
pubmed-meshheading:6147089-Basal Ganglia Diseases,
pubmed-meshheading:6147089-Child,
pubmed-meshheading:6147089-Creatine Kinase,
pubmed-meshheading:6147089-Female,
pubmed-meshheading:6147089-Humans,
pubmed-meshheading:6147089-Infant,
pubmed-meshheading:6147089-Male,
pubmed-meshheading:6147089-Muscles,
pubmed-meshheading:6147089-Recurrence
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pubmed:year |
1984
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pubmed:articleTitle |
Neuroleptic malignant syndrome. Patient with unique clinical and physiologic features.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|