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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1984-9-7
|
| pubmed:abstractText |
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog. It has been selected as a candidate for further clinical study. Structure-activity relationships and structure-duration relationships for these new beta-blockers are also discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1007-16
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6146718-Adrenergic beta-Antagonists,
pubmed-meshheading:6146718-Animals,
pubmed-meshheading:6146718-Dogs,
pubmed-meshheading:6146718-Guinea Pigs,
pubmed-meshheading:6146718-Half-Life,
pubmed-meshheading:6146718-Heart Rate,
pubmed-meshheading:6146718-Humans,
pubmed-meshheading:6146718-Isoproterenol,
pubmed-meshheading:6146718-Propanolamines,
pubmed-meshheading:6146718-Structure-Activity Relationship,
pubmed-meshheading:6146718-Time Factors,
pubmed-meshheading:6146718-Trachea
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
[(Arylcarbonyl)oxy]propanolamines. 1. Novel beta-blockers with ultrashort duration of action.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|