Linked Life Data

6146625

Source:http://linkedlifedata.com/resource/pubmed/id/6146625

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-9-19
pubmed:abstractText
In the pithed normotensive rat the effect of the calcium entry blocker nifedipine was studied on alpha 1-adrenoreceptor-mediated pressor responses of intravenously administered (-)-noradrenaline, dopamine and (-)-adrenaline as well as of (-)-noradrenaline released from sympathetic neurones by DMPP, tyramine, McN-A-343 and electrical stimulation of the spinal cord at the level Th5-L4. The alpha 1-adrenoreceptor-mediated pressor responses to both intravenously administered and neuronally released catecholamines were moderately antagonized by nifedipine. The alpha 1-adrenoreceptor-mediated increase in diastolic pressure elicited by DMPP was unique in its extreme insensitivity to blockade by nifedipine. The results support the hypothesis that phenylethylamine-like alpha 1-adrenoreceptor agonists induce an increase in diastolic pressure relatively independent of extracellular calcium in contrast to imidazolidine-like agonists. The data may be interpreted as indicating that each alpha 1-adrenoreceptor agonist activates the alpha 1-adrenoreceptor in a unique way.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-92
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Interaction between the calcium entry blocker nifedipine with the alpha 1-adrenoreceptor-mediated increase in diastolic pressure elicited by catecholamines.
pubmed:publicationType
Journal Article