6146311

Source:http://linkedlifedata.com/resource/pubmed/id/6146311

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006104, umls-concept:C0007634, umls-concept:C0007804, umls-concept:C0010453, umls-concept:C0013935, umls-concept:C0020268, umls-concept:C0025914, umls-concept:C0026809, umls-concept:C0243127, umls-concept:C0443331, umls-concept:C0851285
pubmed:issue	3
pubmed:dateCreated	1984-8-8
pubmed:abstractText	Myelinogenic cultures of cells dissociated from embryonic mouse brain were used to study the regulation of myelination-associated molecules by cortisol. Cortisol in physiological concentrations (0.03 microM) caused an increased accumulation of myelination-associated sulphogalactolipids. It also stimulated the myelin- and oligodendroglia-specific cyclic nucleotide phosphohydrolase. The increase in sulphogalactolipid content was caused by a cortisol-concentration-dependent inhibition in arylsulphatase A activity and not by an increase in either cerebroside sulphotransferase activity or an increase in availability of adenosine 3'-phosphate 5'-phosphosulphate. Of several steroid hormones tested only the glucocorticoid types brought about these changes. The relationship between net sulphogalactolipid accumulation and arylsulphatase A inhibition induced by cortisol was confirmed by sulphogalactolipid turnover studies. Depending on whether a single-phase or a two-phase decay calculation is used, the turnover of sulphogalactolipid with cortisol present was decreased at 22 days in culture by either 62% or 65% respectively of that without cortisol. This decrease in turnover can be attributed completely to the decrease of arylsulphatase activity by cortisol to 63% of the value for normal cells grown under the same conditions.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/NS-10221
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2984726R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2',3'-Cyclic-Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Cerebroside-Sulfatase, http://linkedlifedata.com/resource/pubmed/chemical/Glycolipids, http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoadenosine Phosphosulfate, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Diester Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Sulfatases, http://linkedlifedata.com/resource/pubmed/chemical/cyclic CMP phosphodiesterase
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0264-6021
pubmed:author	pubmed-author:PieringerR ARA, pubmed-author:StephensJ LJL
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	219
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	689-97
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:6146311-2',3'-Cyclic-Nucleotide Phosphodiesterases, pubmed-meshheading:6146311-Animals, pubmed-meshheading:6146311-Brain, pubmed-meshheading:6146311-Cells, Cultured, pubmed-meshheading:6146311-Cerebroside-Sulfatase, pubmed-meshheading:6146311-Glycolipids, pubmed-meshheading:6146311-Hydrocortisone, pubmed-meshheading:6146311-Mice, pubmed-meshheading:6146311-Myelin Sheath, pubmed-meshheading:6146311-Phosphoadenosine Phosphosulfate, pubmed-meshheading:6146311-Phosphoric Diester Hydrolases, pubmed-meshheading:6146311-Sulfatases
pubmed:year	1984
pubmed:articleTitle	Regulation of arylsulphatase A and sulphogalactolipid turnover by cortisol in myelinogenic cultures of cells dissociated from embryonic mouse brain.

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