Linked Life Data

6146158

Source:http://linkedlifedata.com/resource/pubmed/id/6146158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-8-17
pubmed:abstractText
Serum prolactin (PRL ng/ml) was measured in 7 male patients on cimetidine (CMT) and in 13 on ranitidine (RNT) before therapy and 5, 10, 15 and 30 days after; at the same intervals FSH (ng/ml), LH (ng/ml) and testosterone (ng/ml) were measured in 5 patients too, in order to ascertain hypothalamic, pituitary, gonadal dysfunction caused by H2 histamine blockers. In agreement with other authors, FSH, LH and testosterone were not affected: no statistical difference was found between basal values and the times of follow-up. In RNT-treated patients PRL showed a little, but not significant increase; in CMT-treated group PRL increased with a peak on 10th day (19.41 +/- 2.14 ng/ml vs. 9.50 +/- 1.72 ng/ml; P less than 0.01); on 30th day PRL levels were still higher than basal ones (15.85 +/- 2.38 ng/ml vs. 9.50 +/- 1.72 ng/ml; P less than 0.05). Unlike other trials we observed that PRL rises very early in oral treatment with CMT, perhaps for resetting of inhibiting factors, it trends to decrease and reach basal values shortly after 30th day notwithstanding therapy. It is now widely accepted that H2 blocker's action is on central histaminergic pathways modulating PRL secretion; in our opinion, the measured differences of PRL secretion with CMT and RNT in short term observations, are produced by different crossing of blood-brain barreer.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0033-4979
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-21
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[H2 histamine antagonists and the hypothalamo-hypophyseal-gonadal axis: effect of short-term treatment on serum levels of prolactin, FSH, LH and testosterone in male ulcer patients].
pubmed:publicationType
Journal Article, English Abstract