|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1984-7-9
|
|
pubmed:abstractText |
The influence of smoking an alpha 1-acid glycoprotein (alpha 1-AGP) and serum albumin concentrations and the protein binding of phenytoin and propranolol in healthy volunteers was investigated. alpha 1-AGP concentrations were found to be statistically different (P less than 0.05) in the smokers (mean = 84.3 mg dl-1) versus non-smokers (mean = 62.8 mg dl-1). There was a trend for lower serum albumin concentrations and lower fraction unbound of propranolol in the smokers. Smoking did not affect the protein binding of phenytoin.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-3573
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
214-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6144765-Adult,
pubmed-meshheading:6144765-Blood Proteins,
pubmed-meshheading:6144765-Humans,
pubmed-meshheading:6144765-Male,
pubmed-meshheading:6144765-Middle Aged,
pubmed-meshheading:6144765-Orosomucoid,
pubmed-meshheading:6144765-Pharmaceutical Preparations,
pubmed-meshheading:6144765-Phenytoin,
pubmed-meshheading:6144765-Propranolol,
pubmed-meshheading:6144765-Protein Binding,
pubmed-meshheading:6144765-Serum Albumin,
pubmed-meshheading:6144765-Smoking
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Influence of smoking on serum protein composition and the protein binding of drugs.
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|
pubmed:publicationType |
Journal Article,
Comparative Study
|
