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pubmed-article:6143539pubmed:abstractTextDifferent, dose-dependent effects of verapamil inhalation on histamine-induced bronchoconstriction in anaesthetized dogs are reported. Cumulative histamine dose-response curves were obtained on three groups each consisting of six dogs. These groups were: A - after atropine sulphate (1 mg/kg); B - after atropine sulphate and verapamil (approximately 0.5 mg/kg); C - after atropine sulphate and verapamil (approximately 5.0 mg/kg). Total lung resistance (R1) was measured as the indicator of bronchoconstriction. The mean maximal response of R1 in B was significant greater (p less than 0.01) than in A and C, while no significant difference was observed between A and C. A possible mechanism is postulated.lld:pubmed
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pubmed-article:6143539pubmed:articleTitleDifferent, dose-dependent effects of verapamil inhalation on histamine-induced bronchoconstriction in anaesthetized dogs.lld:pubmed
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pubmed-article:6143539pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed