Linked Life Data

6142768

Source:http://linkedlifedata.com/resource/pubmed/id/6142768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-5-24
pubmed:abstractText
A rapid decrease in the translational efficiency of mRNA synthesized during vegetative growth is associated with the initiation of development in Dictyostelium discoideum. In contrast, newly synthesized mRNA associates with polysomes with high efficiency. Discrimination between these two mRNA populations correlates with a rapid shortening of the poly(A) tract on the preexisting mRNA. A model is proposed in which a critical poly(A) length regulates the pattern of protein synthesis by affecting the efficiency with which mRNAs can interact with the translational machinery. The model suggests that transcriptional and translational controls can be coupled by altering the state of adenylation of the preexisting mRNA population. The model allows radical changes in the pattern of protein synthesis without wholesale destruction of preexisting mRNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1017-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Translational control during early Dictyostelium development: possible involvement of poly(A) sequences.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't