Linked Life Data

6141796

Source:http://linkedlifedata.com/resource/pubmed/id/6141796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-3-8
pubmed:abstractText
A nucleoside triphosphate (NTP) pyrophosphohydrolase was previously demonstrated in human chondrocalcinotic and osteoarthritic articular cartilage. In this study, grinding and enzymatic techniques for cartilage subcellular fractionation were compared. It was shown that this enzyme was concentrated in fractions enriched in plasma membranes. The enzyme had the same activity in cartilage slices as in triton X-100 extracts, and all of the activity was removed by preliminary treatment of cartilage slices with pronase. Histologic separation of cartilages into tangential and upper radial versus lower radial zones indicated no difference in concentrations of this enzyme. A role is postulated for this enzyme in metabolic chondrocytic plasma membrane responses to injury or destabilization from other causes, such as rapid synthesis or cell division.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-3591
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
NTP pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. II. Further studies on histologic and subcellular distribution.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't