Linked Life Data

6141505

Source:http://linkedlifedata.com/resource/pubmed/id/6141505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-3-2
pubmed:abstractText
To investigate the role of multiple opiate receptors in spinal mechanisms of antinociception the activity of various opiate receptor agonists was determined against different nociceptive stimuli in the mouse and rat. Intrathecal administration of the putative kappa-receptor agonists dynorphin A (DYN), bremazocine, and ethylketocyclazocine, as well as the delta-agonist D-Ala2,D-Leu5-enkephalin and the mu-agonists, Tyr-D-Ala-Gly-MePhe-NH-(CH2)2OH and morphine resulted in a dose-dependent antinociceptive effect. The order of potencies was similar for visceral and thermal pain. Inhibition of writhing in mice was much more strongly antagonized by MR 2266 than by naloxone, and des-Tyr1-DYN1-13 was 50 times less potent than DYN in this test suggesting that DYN acts through the kappa-receptor. It is concluded that mu-, delta- and kappa-opiate receptors are involved in spinally mediated antinociception related to kinds of noxious stimuli.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
33 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
649-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Analgesic effects of mu-, delta- and kappa-opiate agonists and, in particular, dynorphin at the spinal level.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't