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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1984-3-2
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pubmed:abstractText |
The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR. Dyn A-IR was released from hippocampal slices in vitro by a Ca++-dependent mechanism stimulated by superfusion with K+, kainate or veratrine. Released peptides were resolved by C18-HPLC and shown to contain Dyn A-IR co-eluting with synthetic Dyn A(1-17). These observations are consistent with the hypothesis that Dyn A(1-17) acts as a neurotransmitter at synapses in hippocampus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6141483-Animals,
pubmed-meshheading:6141483-Calcium,
pubmed-meshheading:6141483-Chromatography, High Pressure Liquid,
pubmed-meshheading:6141483-Dynorphins,
pubmed-meshheading:6141483-Endorphins,
pubmed-meshheading:6141483-Hippocampus,
pubmed-meshheading:6141483-Kainic Acid,
pubmed-meshheading:6141483-Male,
pubmed-meshheading:6141483-Neurotransmitter Agents,
pubmed-meshheading:6141483-Peptide Fragments,
pubmed-meshheading:6141483-Rats,
pubmed-meshheading:6141483-Rats, Inbred Strains,
pubmed-meshheading:6141483-Veratrine
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pubmed:year |
1983
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pubmed:articleTitle |
Evidence for dynorphin-A as a neurotransmitter in rat hippocampus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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