| pubmed-article:6141335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6141335 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:6141335 | lifeskim:mentions | umls-concept:C0013072 | lld:lifeskim |
| pubmed-article:6141335 | lifeskim:mentions | umls-concept:C1096063 | lld:lifeskim |
| pubmed-article:6141335 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:6141335 | pubmed:issue | 8370 | lld:pubmed |
| pubmed-article:6141335 | pubmed:dateCreated | 1984-3-2 | lld:pubmed |
| pubmed-article:6141335 | pubmed:abstractText | Twenty-four patients with frequent drug-resistant seizures took part in a randomised double-blind placebo-controlled crossover trial of the GABA-transaminase inhibitor, gamma-vinyl GABA. It was added to their usual drug treatment in a dose of 3 g daily. The total number of seizures during the 9-week active treatment period was less than that in the placebo period (p less than 0.001, two-way analysis of variance). The greatest effect was on complex partial seizures. Mean weekly seizure frequency (complex partial and tonic-clonic) was 6.2 fits/week for the placebo period and 3.5 fits/week for the gamma-vinyl GABA period. Adverse effects, particularly drowsiness and mood changes, occurred more often during administration of active drug. Serum concentrations of phenytoin were lower during gamma-vinyl GABA treatment than during placebo (p less than 0.05), but the concentrations of other anticonvulsants given concomitantly did not change. These results suggest that gamma-vinyl GABA is an effective antiepileptic compound. | lld:pubmed |
| pubmed-article:6141335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6141335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6141335 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6141335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6141335 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6141335 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:6141335 | pubmed:author | pubmed-author:RichensAA | lld:pubmed |
| pubmed-article:6141335 | pubmed:author | pubmed-author:RimmerE MEM | lld:pubmed |
| pubmed-article:6141335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6141335 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:6141335 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:6141335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6141335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6141335 | pubmed:pagination | 189-90 | lld:pubmed |
| pubmed-article:6141335 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6141335 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6141335 | pubmed:articleTitle | Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy. | lld:pubmed |
| pubmed-article:6141335 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6141335 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:6141335 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:6141335 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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