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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8370
|
pubmed:dateCreated |
1984-3-2
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pubmed:abstractText |
Intestinal permeability was investigated with a chromium-51-EDTA (edetic acid) absorption test in 36 non-intoxicated alcoholic patients without liver cirrhosis or overt clinical evidence of malabsorption or malnutrition. Patients abstaining from alcohol for less than 4 days almost invariably had higher intestinal permeability than controls, and in many the abnormality persisted for up to 2 weeks after cessation of drinking. The presence of gastritis did not correlate with the presence of increased permeability. The site of altered intestinal permeability was shown by an in-vitro permeability test to be the small bowel. The increased intestinal permeability to toxic "non-absorbable" compounds of less than 5000 molecular weight may account for some of the extraintestinal tissue damage common in alcoholic patients.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0140-6736
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
28
|
pubmed:volume |
1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
179-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6141332-Alcoholism,
pubmed-meshheading:6141332-Chromium Radioisotopes,
pubmed-meshheading:6141332-Edetic Acid,
pubmed-meshheading:6141332-Ethanol,
pubmed-meshheading:6141332-Humans,
pubmed-meshheading:6141332-Intestinal Absorption,
pubmed-meshheading:6141332-Intestine, Small,
pubmed-meshheading:6141332-Jejunum,
pubmed-meshheading:6141332-Molecular Weight,
pubmed-meshheading:6141332-Nutrition Disorders,
pubmed-meshheading:6141332-Permeability
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pubmed:year |
1984
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pubmed:articleTitle |
The leaky gut of alcoholism: possible route of entry for toxic compounds.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|