rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1984-3-2
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pubmed:abstractText |
Three stereoisomers of yohimbine (corynanthine, rauwolscine and yohimbine) have been used to characterize alpha-adrenoceptors in rat aortic strips. pA2 values for each antagonist were calculated using 3 different agonists ((-)-noradrenaline, (-)-phenylephrine and guanfacine) which possess varying affinities for alpha 1 and alpha 2 receptors. Mean pA2 values were not significantly different irrespective of the agonist used and the order of the potency was corynanthine greater than yohimbine greater than rauwolscine. The results are consistent with the presence of alpha 1-adrenoceptors in rat aorta.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Guanfacine,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylacetates,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6141061-Adrenergic alpha-Agonists,
pubmed-meshheading:6141061-Adrenergic alpha-Antagonists,
pubmed-meshheading:6141061-Animals,
pubmed-meshheading:6141061-Female,
pubmed-meshheading:6141061-Guanfacine,
pubmed-meshheading:6141061-Guanidines,
pubmed-meshheading:6141061-Male,
pubmed-meshheading:6141061-Muscle, Smooth, Vascular,
pubmed-meshheading:6141061-Muscle Contraction,
pubmed-meshheading:6141061-Norepinephrine,
pubmed-meshheading:6141061-Phenylacetates,
pubmed-meshheading:6141061-Phenylephrine,
pubmed-meshheading:6141061-Rats,
pubmed-meshheading:6141061-Rats, Inbred Strains,
pubmed-meshheading:6141061-Receptors, Adrenergic, alpha,
pubmed-meshheading:6141061-Stereoisomerism,
pubmed-meshheading:6141061-Yohimbine
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pubmed:year |
1983
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pubmed:articleTitle |
Effects of yohimbine stereoisomers on contractions of rat aortic strips produced by agonists with different selectivity for alpha 1- and alpha 2-adrenoceptors.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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