Linked Life Data

6138749

Source:http://linkedlifedata.com/resource/pubmed/id/6138749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-12-17
pubmed:abstractText
Voltage clamp experiments were done on single myelinated nerve fibres of the frog, Rana esculenta, with 10 mM TEA+ in the external solutions to block potassium channels. Iodate (20, 40 or 100 mM KIO3) was applied to the axoplasmic side of the nodal membrane by diffusion from a cut internode. The effect of 20 mM started within a few minutes and reached a stationary value after ca. 20 min which was maintained for another 15 min. The size of the effect was independent of the iodate concentrations tested. Iodate action could not be reversed even after only a 2-min application. When the effect was fully established, iodate increased the faster time constant of inactivation ca. 1.2 times, the slower one ca. 1.7 times. Iodate also induced a persistent (for seconds) INa component that was, at the end of a 15-ms pulse (I15ms), 6% of the early peak INa of the control. Experiments with conditioning prepulses revealed a non-monotonic h infinity -V curve in iodate with finite h infinity values throughout. Increasing [Ca2+]0 from 2 to 10 mM shifted peak INa (V) and I15ms (V) by 10-15 mV to more positive potentials. In contrast, as shown in previous experiments, I15ms induced by sea anemone toxin ATX II was nearly abolished (h infinity approximately equal to 0) for 60 less than V less than 80 mV on increasing [Ca2+]0.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
398
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
204-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't